What are the values of PKA in organic chemistry?
pKa Data Compiled by R. Williams page-1 pKa Values INDEX Inorganic 2 Phenazine 24 Phosphates 3 Pyridine 25 Carboxylic acids 4, 8 Pyrazine 26 Aliphatic 4, 8 Aromatic 7, 8 Quinoline 27 Phenols 9 Quinazoline 27 Alcohols and oxygen acids 10, 11 Quinoxaline 27 Amino Acids 12 Special Nitrogen Compounds 28 Peptides 13 Hydroxylamines 28
What is the substrate specificity of PKA?
These kinases share a substrate specificity characterized by Arg at position 3 relative to the phosphorylated serine or threonine. The second messenger cyclic AMP (cAMP) activates PKA in mammalian cells and controls many cellular mechanisms such as gene transcription, ion transport, and protein phosphorylation2.
What type of microplate reader is required for the pKa kit?
A 96-well microplate reader capable of reading optical density at 450 and 650 nm is required for use of this kit. PKA is a member of an important class of kinases, referred to as Arg-directed kinases or AGC-family kinases, that includes cAMP-dependent protein kinase (PKA or cAPK), cGMP-dependent protein kinase (PKG), protein kinase C, Akt, and RSK.
What is the PKA activity research-use-only kit?
The PKA Activity research-use-only kit is a colorimetric activity assay designed for the quantification and detection of protein kinase A activity in cell lysates, tissue extracts and buffer samples.
What is the pKa of trichloroacetic acid?
The pKa of trichloroacetic acid is 0.51 (4), indicating that this compound will primarily exist in anion form in the environment and anions generally do not adsorb more strongly to soils containing organic carbon and clay than their neutral counterparts (5). (1) Hansch C et al; Exploring QSAR. Hydrophobic, Electronic, and Steric Constants.
What are the PKA and pi values of amino acids?
pKa and pI values of amino acids Amino acid 3-letter code 1-letter code pKa Cα -COOH pKa Cα -NH 3 + pKa side chain Isoelectric point (pI) Alanine Ala A 2.34 9.69 – 6.02 Arginine Arg R 2.17 9.04 12.48 10.76 Asparagine Asn N 2.02 8.80 – 5.41 Aspartic acid Asp D 2.09 9.82 3.86 2.98
Is trichloroacetic acid carcinogenic to humans?
Evaluation: There is inadequate evidence in humans for the carcinogenicity of trichloroacetic acid. There is limited evidence in experimental animals for the carcinogenicity of trichloroacetic acid. Overall evaluation: Trichloroacetic acid is not classifiable as to its carcinogenicity to humans (Group 3). IARC.