Is BCL-xL pro or anti-apoptotic?
BCL-xL/BCL2L1 is a critical anti-apoptotic protein that promotes the survival of differentiating pancreatic cells from human pluripotent stem cells.
Where is BCL-xL expressed?
In this study, we demonstrated that Bcl-xL was overexpressed in liver tumors. Bcl-xL was localized mainly in the cytoplasm and mitochondria of both normal and cancer cells. It is interesting that Bcl-xL expression was also found in the nuclei of liver cancer cells in the tumor margins.
Is BCL-2 pro or anti-apoptotic?
Abstract. Apoptosis is an essential physiological process for the selective elimination of cells, which is involved in a variety of biological events. The Bcl-2 family is the best characterized protein family involved in the regulation of apoptotic cell death, consisting of anti-apoptotic and pro-apoptotic members.
What does BCL-2 protein do?
BCL-2 family proteins are the regulators of apoptosis, but also have other functions. This family of interacting partners includes inhibitors and inducers of cell death. Together they regulate and mediate the process by which mitochondria contribute to cell death known as the intrinsic apoptosis pathway.
How is BCL2 activated in apoptosis?
The BCL-2 family of proteins controls cell death primarily by direct binding interactions that regulate mitochondrial outer membrane permeabilization (MOMP) leading to the irreversible release of intermembrane space proteins, subsequent caspase activation and apoptosis.
What is the role of BCL2 in apoptosis?
BCL2 prevents BAX/BAK oligomerization, which would otherwise lead to the release of several apoptogenic molecules from the mitochondrion. It is also known that BCL2 binds to and inactivates BAX and other pro-apoptotic proteins, thereby inhibiting apoptosis.
How does Bcl-xL work?
Bcl-xL inhibits the activation of Bax and Bak, preventing a loss of mitochondrial outer membrane (MOM) integrity and release of cytochrome c into the cytoplasm. Therefore, the Bcl-xL isoform is anti-apoptotic.
Is BCL-xL a protein?
Bcl-XL: A multifunctional anti-apoptotic protein. The apoptosis inhibitor Bcl-xL controls breast cancer cell migration through mitochondria-dependent reactive oxygen species production. BCL-xL, a Mitochondrial Protein Involved in Successful Aging: From C. elegans to Human Centenarians.
How does Bcl xL work?
Is Bcl-2 a tumor suppressor?
Apoptosis-Suppressing Oncoprotein Bcl-2 Bcl-2 is widely believed to be an apoptosis suppressor gene. Overexpression of the protein in cancer cells may block or delay onset of apoptosis, by selecting and maintaining long-living cells and arresting cells in the G0 phase of the cell cycle.
How does Bcl-2 regulate apoptosis?
How does BCL-xL work?
Is BCL-2 a Tumour suppressor?
Bcl-2 is widely believed to be an apoptosis suppressor gene. Overexpression of the protein in cancer cells may block or delay onset of apoptosis, by selecting and maintaining long-living cells and arresting cells in the G0 phase of the cell cycle.
What does BCL2 negative mean?
BCL-2 is negative in the monocytoid B-cells in reactive processes (such as that seen in cases of lymph nodes with toxoplasmosis), but up to 79% of cases of marginal zone B-cell lymphoma are positive with BCL- 2.