What is recommended when taking dolutegravir?
How do I take dolutegravir? You can usually take dolutegravir with or without food. If you are prescribed dolutegravir to be taken twice a day, your doctor will advise you to take it with food. HIV treatment works best if you take it every day.
What is dolutegravir 50mg?
Dolutegravir is in a class of medications called HIV integrase inhibitors. It works by decreasing the amount of HIV in your blood and increasing the number of immune cells that help fight infections in your body.
Can dolutegravir be taken alone?
A potent antiretroviral medication — the integrase inhibitor dolutegravir (Tivicay) — may be able to suppress HIV when used with just one other well-tolerated drug, and may be able to keep viral load undetectable when used alone, according to studies presented at the 15th European AIDS Conference last month in …
How long does dolutegravir stay in the body?
At 96 hours after the last dose, dolutegravir remained detectable in all participants and above the IC90 in 4 of 17. At 72 hours elvitegravir remained detectable in 9 of 17 participants, all below the IC90.
How long does it take for dolutegravir to work?
Official answer. Triumeq works quickly to suppress the HIV-1 virus and some people have reported an undetectable viral load within a month of starting Triumeq (corresponds to an HIV‑1 RNA level of fewer than 50 copies/mL).
What type of ARV is dolutegravir?
Dolutegravir was first approved by the United States Food and Drug Administration in 2013. It is part of a class of antiretroviral medicine called integrase inhibitors.
Does dolutegravir increase appetite?
Observational data from Nigeria, presented at HIV Glasgow 2020, showed weight gain in people with HIV switching to dolutegravir (DTG)-based ART. This appeared to plateau by 24 months follow up. An increase in appetite was a commonly self-reported side-effect among participants in the study.
Can dolutegravir make you gain weight?
Although weight gain can occur after starting any class of antiretroviral drug, it has most frequently been reported among those taking potent integrase inhibitors, including dolutegravir (Tivicay, also in the Triumeq, Juluca and Dovato coformulations), and tenofovir alafenamide (TAF), the newer version of the drug in …
Can I switch from dolutegravir to efavirenz?
Patients who have undesirable weight gain on dolutegravir could request to switch back to efavirenz in the hope that their weight will return to where it was before. Both dolutegravir and efavirenz interact with other drugs (don’t mix well in the body).
What is the best time of day to take dolutegravir?
Management: Administer dolutegravir at least 2 hours before or 6 hours after oral iron. Administer dolutegravir/rilpivirine at least 4 hours before or 6 hours after oral iron. Alternatively, dolutegravir and oral iron can be taken together with food.
What is the optimal dose of dolutegravir for efavirenz for treatment-naive patients?
For treatment-naive patients or treatment-experienced but INSTI-naive patients who weigh at least 40 kg, the dose of dolutegravir should be increased to 50 mg PO twice daily when administered with efavirenz.
How is systemic exposure to dolutegravir prevented?
Coadministration with medications containing polyvalent cations decrease dolutegravir systemic exposure; give dolutegravir 2 hours before or 6 hours after polyvalent cations (e.g., antacids, laxatives, sucralfate, iron supplements, calcium supplements, buffered medications)
How much dolutegravir should I take for INSTI?
Management: Increase dolutegravir to 50 mg twice daily in adults and pediatric patients (12 yrs or older and at least 40 kg). Seek alternatives to fosamprenavir/ritonavir in INSTI-experienced patients with suspected or certain INSTI resistance.