What does cytopenia mean?
Listen to pronunciation. (SY-toh-PEE-nee-uh) A condition in which there is a lower-than-normal number of blood cells.
What is the cause of cytopenia?
The possible causes of cytopenia are complex and varied. Among these causes are peripheral destruction, infections, and side effects of medication. Two types of cytopenia that are related to the underlying cause of the low blood cell count are autoimmune cytopenia and refractory cytopenia.
Is neutropenia a cytopenia?
Cytopenia, defined by a reduced number of blood cells manifesting as either anemia, neutropenia, and/or thrombocytopenia (1), may be associated with multiple conditions, including cancer, bone marrow suppression from chemotherapy or radiotherapy, as well as pregnancy, nutrient deficiencies, liver disease, hypersplenism …
What is neutropenia autoimmune?
Autoimmune neutropenia (AIN) is a rare hematological disorder characterized by the autoantibody-induced destruction of neutrophils. The primary mechanism for this is opsonization, which accelerates the phagocytic clearance of neutrophils.
What is the opposite of cytopenia?
Philadelphia-negative chronic myeloproliferative disorders (polycythemia vera, essential thrombocythemia, primary myelofibrosis) are characterized by various combinations of erythrocytosis, leukocytosis and thrombocytosis, i.e., the opposite of cytopenia.
What is peripheral cytopenia?
Peripheral pancytopenia is a syndrome which allows for an early diagnosis, and although is may cover a large number of pathological entities, it can be clearly defined into three groups of illnesses which evolve with this syndromal manifestations.
What autoimmune disease causes low WBC?
General Discussion. Evans syndrome is a rare disorder in which the body’s immune system produces antibodies that mistakenly destroy red blood cells, platelets and sometimes certain white blood cell known as neutrophils. This leads to abnormally low levels of these blood cells in the body (cytopenia).
What is peripheral blood cytopenia?
Peripheral blood cytopenias may precede the development of hematological malignancies and frequently pose clinical challenges in the older population. The natural course of (mild) cytopenias during aging and their association with hematological disorders in community-dwelling individuals are not well studied.
Will a person with autoimmune neutropenia have a normal life?
Although the blood level of neutrophils can be very low in children with autoimmune neutropenia, they are only rarely affected by severe bacterial infections and neutropenia usually resolves without treatment several months to years after onset.
Can autoimmune neutropenia go away?
It is a self-limited condition, with more than 95% of children recovering normal neutrophil counts within 2 years. Patients can be managed with prophylactic antibiotics and rarely need further intervention.
Can Vitamin B12 deficiency cause low platelets?
Low platelet counts are sometimes associated with vitamin B12 deficiencies, per March 2012 research in the Journal of Family Medicine and Primary Care.
How is autoimmune neutropenia treated?
Autoimmune neutropenia has been treated with corticosteroids, intravenous immunoglobulin, and G-CSF. Approximately half the patients responded to intravenous immunoglobulin, but neutrophil counts remained elevated for only 1 week.